Synthesis, characterization and in vitro evaluation of novel enantiomerically-pure sulphonamide antimalarials

• Main Authors: Anusha, Sebastian, Sinha, Ameya, Babu Rajeev, C. P., Chu, Trang T. T., Mathai, Jessin, Huang, Ximei, Fuchs, Julian E., Shivananju, NanjundaSwamy, Bender, Andreas, Preiser, Peter Rainer, Rangappa, Kanchugarakoppal S., Basappa, Chandramohanadas, Rajesh
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Drug discovery; Giemsa-staining; Microscopy; Flow cytometry; Anti-malarials; Plasmodium falciparum; In-vitro screening
• Online Access: https://hdl.handle.net/10356/81894; http://hdl.handle.net/10220/39739
• Institution: Nanyang Technological University

Malaria parasites are currently gaining drug-resistance rapidly, across countries and continents. Hence, the discovery and development of novel chemical scaffolds, with superior antimalarial activity remain an important priority, for the developing world. Our report describes the development, charac...