Revisiting Frank-Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (k_tr) in a length-dependent fashion

• Main Authors: Toepfer, Christopher N., West, Timothy G., Ferenczi, Michael Alan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Cardiac; Regulatory light chain
• Online Access: https://hdl.handle.net/10356/82094; http://hdl.handle.net/10220/41034
• Institution: Nanyang Technological University

Force and power in cardiac muscle have a known dependence on phosphorylation of the myosin-associated regulatory light chain (RLC). We explore the effect of RLC phosphorylation on the ability of cardiac preparations to redevelop force (ktr ) in maximally activating [Ca2+ ]. Activation was achieved b...