Molecular nonlinear dynamics and protein thermal uncertainty quantification

• Main Authors: Xia, Kelin, Wei, Guo-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Proteins; Protein folding
• Online Access: https://hdl.handle.net/10356/82121; http://hdl.handle.net/10220/41112
• Institution: Nanyang Technological University

This work introduces molecular nonlinear dynamics (MND) as a new approach for describing protein folding and aggregation. By using a mode system, we show that the MND of disordered proteins is chaotic while that of folded proteins exhibits intrinsically low dimensional manifolds (ILDMs). The stabili...