Meta-analysis of transcriptome reveals let-7b as an unfavorable prognostic biomarker and predicts molecular and clinical subclasses in high-grade serous ovarian carcinoma

• Main Authors: Tang, Zhiqun, Ow, Ghim Siong, Thiery, Jean Paul, Ivshina, Anna V., Kuznetsov, Vladimir A.
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: High-grade serous ovarian carcinoma; MicroRNA let-7
• Online Access: https://hdl.handle.net/10356/82158; http://hdl.handle.net/10220/41100
• Institution: Nanyang Technological University

High-grade serous ovarian carcinoma (HG-SOC) is a heterogeneous, poorly classified, lethal disease that frequently exhibits altered expressions of microRNAs. Let-7 family members are often reported as tumor suppressors; nonetheless, clinicopathological functions and prognostic values of individual l...