Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

High-grade serous ovarian cancer (HG-SOC), a major histologic type of epithelial ovarian cancer (EOC), is a poorly-characterized, heterogeneous and lethal disease where somatic mutations of TP53 are common and inherited loss-of-function mutations in BRCA1/2 predispose to cancer in 9.5–13% of EOC pat...

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Bibliographic Details
Main Authors: Ow, Ghim Siong, Ivshina, Anna V., Fuentes, Gloria, Kuznetsov, Vladimir A.
Other Authors: School of Computer Engineering
Format: Article
Language:English
Published: 2016
Subjects:
RPS6KA2
MLL4
CHEK2
Mutations
Cancer driver mutation
High-grade serous ovarian carcinoma
Cancer sub-type
Biomarker
Gene signature
Survival analysis
Diagnostics
Prognosis
Patient’s stratification
Chemotherapy resistance
Online Access:https://hdl.handle.net/10356/82783
http://hdl.handle.net/10220/40276
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/82783
http://hdl.handle.net/10220/40276

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