Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

High-grade serous ovarian cancer (HG-SOC), a major histologic type of epithelial ovarian cancer (EOC), is a poorly-characterized, heterogeneous and lethal disease where somatic mutations of TP53 are common and inherited loss-of-function mutations in BRCA1/2 predispose to cancer in 9.5–13% of EOC pat...

Saved in:

書目詳細資料
Main Authors:	Ow, Ghim Siong, Ivshina, Anna V., Fuentes, Gloria, Kuznetsov, Vladimir A.
其他作者:	School of Computer Engineering
格式:	Article
語言:	English
出版:	2016
主題:	RPS6KA2 MLL4 CHEK2 Mutations Cancer driver mutation High-grade serous ovarian carcinoma Cancer sub-type Biomarker Gene signature Survival analysis Diagnostics Prognosis Patient’s stratification Chemotherapy resistance
在線閱讀:	https://hdl.handle.net/10356/82783 http://hdl.handle.net/10220/40276
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

相似書籍

AB109. Novel constitutional and somatic RB1 mutations underlying retinal cancers in addition to TNFα, KIF13A and MGMT alterations
由: SWATI TOMAR, et al.
出版: (2020)

BRCA1 mutations in the family history clinic
由: IAU TSAU CHOONG, PHILIP
出版: (2010)

COMPUTATIONAL ANALYSIS OF SOMATIC MUTATIONS IN GASTROINTESTINAL CANCER WHOLE GENOMES
由: HUANG WEITAI
出版: (2019)

ENIGMA CHEK2gether project: a comprehensive study identifies functionally impaired CHEK2 germline missense variants associated with increased breast cancer risk
由: Stolarova, Lenka, et al.
出版: (2024)

Patient survival and tumor characteristics associated with CHEK2:p.I157T - findings from the Breast Cancer Association Consortium
由: Muranen, T.A, et al.
出版: (2020)

DE-ORPHANISING HIGHLY RECURRENT NON-CODING MUTATIONS IN CANCER
由: CHUA BOON HAOW
出版: (2020)

Meta-analysis of transcriptome reveals let-7b as an unfavorable prognostic biomarker and predicts molecular and clinical subclasses in high-grade serous ovarian carcinoma
由: Tang, Zhiqun, et al.
出版: (2016)

Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians
由: Han, Mi-Ryung, et al.
出版: (2021)

Screening of mutation of BRCA1 in Thai breast cancer patients by Single-Stranded Conformation Polymorphism (SSCP)
由: Pornpen Panomwan
出版: (2006)

Meta-analysis of transcriptome reveals let-7b as an unfavorable prognostic biomarker and predicts molecular and clinical subclasses in high-grade serous ovarian carcinoma
由: Tang, Z., et al.
出版: (2014)

MUTATIONAL SIGNATURES AND THEIR APPLICATION TO DETECT AA EXPOSURE IN CANCER
由: NG WEI TIAN, ALVIN
出版: (2020)

Molecular detection and characterization of KRAS mutations among patients with colorectal adenocarcinoma in a tertiary hospital in Metro Manila
由: Nuylan, Michelle L.
出版: (2009)

The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients
由: Tan E.K., et al.
出版: (2018)

Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets
由: Kuznetsov, Vladimir A., et al.
出版: (2018)

Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese
由: Liang, X., et al.
出版: (2012)

Detection and characterization of mutations in the mismatch repair gene of a Filipino family with HNPCC (Hereditary Nonpolyposis Colorectal Cancer)
由: Evangelista, Ana Barbara S.
出版: (2004)

MULTI-DIMENSIONAL INTERROGATION OF DNA MUTATIONS IN CANCER
由: MOHAMED FEROZ BIN MOHAMMED OMAR
出版: (2017)

Recurring MLH1 deleterious mutations in unrelated Chinese Lynch syndrome families in Singapore
由: Yap, H.-L., et al.
出版: (2014)

Antimutagenicity of some natural red colors introduced to steamed starchy dessert by somatic mutation and recombination test
由: Nawanwat Sinseubpol
出版: (2012)

Detection and characterization of mutation in mismatch repair genes in a filipino family with HNPCC (Hereditary Nonpolyposis Colorectal Cancer)
由: Evangelista, Ana Barbara S.
出版: (2004)

Insights into the effects of cancer associated mutations at the upf2 and atp-binding sites of nmd master regulator: Upf1
由: Kalathiya, U., et al.
出版: (2021)

SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F
由: Koren-Michowitz, M., et al.
出版: (2016)

Multiple signatures of a disease in potential biomarker space : getting the signatures consensus and identification of novel biomarkers
由: Ow, Ghim Siong, et al.
出版: (2018)

JAK2 mutations in Asian patients with essential thrombocythaemia
由: Wong, G.-C., et al.
出版: (2016)

Experience from Asian centers in a named-patient-use program for afatinib in patients with advanced non-small-cell lung cancer who had progressed following prior therapies, including patients with uncommon EGFR mutations
由: Chang, Gee-Chen, et al.
出版: (2022)

Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore
由: Shi, C.Y., et al.
出版: (2012)

Effects of EthyI Methane Sulfonate (EMS) on Mutation of Upland Rice (Oryza sativa L.)
由: Awais Ali
出版: (2024)

Sirtuin2 in the CNS: Expression, functional roles, action mechanism and mutation-induced alteration of molecular /cell biological properties
由: LI WENBO
出版: (2010)

Point mutations in the RUNX1/AML1 gene: Another actor in RUNX leukemia
由: Osato, M.
出版: (2011)

Functional Analysis of Familial Asp67Glu and Thr1051Ser BRCA1 Mutations in Breast/Ovarian Carcinogenesis
由: Malinee Pongsavee, et al.
出版: (2012)

Molecular analysis of mutations in Agrobacterium tumefaciens under selection pressure
由: QIAN ZHUOLEI
出版: (2010)

Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC)
由: Lim, E.H., et al.
出版: (2011)

Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC)
由: Lim, E.H., et al.
出版: (2014)

Molecular biology changes associated with LRRK2 mutations in Parkinson's disease
由: Yi, W.L., et al.
出版: (2014)

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
由: Pritchard, C.C, et al.
出版: (2020)

EVALUATION OF SOFTWARE FOR MUTATIONAL SIGNATURE DISCOVERY
由: WU YANG
出版: (2022)

Suppression of different classes of somatic mutations in Arabidopsis by vir gene-expressing Agrobacterium strains
由: Shah, J.M, et al.
出版: (2020)

Lack of somatic mutations in EGFR tyrosine kinase domain in hepatocellular and nasopharyngeal carcinoma
由: Lee, S.-C., et al.
出版: (2012)

Mutation Induction of In Vitro Chrysanthemum by Gamma Irradiation
由: Vichai Puripunyavanich, et al.
出版: (2019)

Gene mutation of thiopurine S-methyltransferase in Uygur Chinese
由: Zhang, J.-P., et al.
出版: (2014)