Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

High-grade serous ovarian cancer (HG-SOC), a major histologic type of epithelial ovarian cancer (EOC), is a poorly-characterized, heterogeneous and lethal disease where somatic mutations of TP53 are common and inherited loss-of-function mutations in BRCA1/2 predispose to cancer in 9.5–13% of EOC pat...

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書目詳細資料
Main Authors:	Ow, Ghim Siong, Ivshina, Anna V., Fuentes, Gloria, Kuznetsov, Vladimir A.
其他作者:	School of Computer Engineering
格式:	Article
語言:	English
出版:	2016
主題:	RPS6KA2 MLL4 CHEK2 Mutations Cancer driver mutation High-grade serous ovarian carcinoma Cancer sub-type Biomarker Gene signature Survival analysis Diagnostics Prognosis Patient’s stratification Chemotherapy resistance
在線閱讀:	https://hdl.handle.net/10356/82783 http://hdl.handle.net/10220/40276
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

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