Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

• Main Authors: Ow, Ghim Siong, Ivshina, Anna V., Fuentes, Gloria, Kuznetsov, Vladimir A.
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: RPS6KA2; MLL4; CHEK2; Mutations; Cancer driver mutation; High-grade serous ovarian carcinoma; Cancer sub-type; Biomarker; Gene signature; Survival analysis; Diagnostics; Prognosis; Patient’s stratification; Chemotherapy resistance
• Online Access: https://hdl.handle.net/10356/82783; http://hdl.handle.net/10220/40276
• Institution: Nanyang Technological University

High-grade serous ovarian cancer (HG-SOC), a major histologic type of epithelial ovarian cancer (EOC), is a poorly-characterized, heterogeneous and lethal disease where somatic mutations of TP53 are common and inherited loss-of-function mutations in BRCA1/2 predispose to cancer in 9.5–13% of EOC pat...