Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

• Main Authors: Hew, Kelly, Dahlroth, Sue-Li, Veerappan, Saranya, Pan, Lucy Xin, Cornvik, Tobias, Nordlund, Pär
• Other Authors: Roujeinikova, Anna
• Format: Article
• Language: English
• Published: 2016
• Subjects: fluorometry; drug targeting
• Online Access: https://hdl.handle.net/10356/82348; http://hdl.handle.net/10220/39978
• Institution: Nanyang Technological University

Varicella zoster virus (VZV) is a highly infectious human herpesvirus that is the causative agent for chicken pox and shingles. VZV encodes a functional thymidylate synthase (TS), which is the sole enzyme that produces dTMP from dUMP de novo. To study substrate binding, the complex structure of TSVZ...