Not just an adhesion molecule : LFA-1 contact tunes the T lymphocyte program

• المؤلفون الرئيسيون: Verma, Navin Kumar, Kelleher, Dermot
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: DRNTU::Science::Medicine; LFA-1; T Lymphocytes
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82500; http://hdl.handle.net/10220/49072

The αLβ2 integrin LFA-1 is known to play a key role in T lymphocyte migration, which is necessary to mount a local immune response, and is also the main driver of autoimmune diseases. This migration-triggering signaling process in T cells is tightly regulated to permit an immune response that is app...