Adaptor regulation of LFA-1 signaling in T lymphocyte migration : potential druggable targets for immunotherapies?

• Main Authors: Verma, Navin K., Kelleher, Dermot
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/107023; http://hdl.handle.net/10220/25253; http://dx.doi.org/10.1002/eji.201344428
• Institution: Nanyang Technological University

The integrin lymphocyte function associated antigen-1 (LFA-1) plays a key role in leukocyte trafficking and in adaptive immune responses through interactions with adhesive ligands, such as ICAM-1. Specific blockade of these interactions has validated LFA-1 as a therapeutic target in many chronic inf...