Adaptor regulation of LFA-1 signaling in T lymphocyte migration : potential druggable targets for immunotherapies?
The integrin lymphocyte function associated antigen-1 (LFA-1) plays a key role in leukocyte trafficking and in adaptive immune responses through interactions with adhesive ligands, such as ICAM-1. Specific blockade of these interactions has validated LFA-1 as a therapeutic target in many chronic inf...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/107023 http://hdl.handle.net/10220/25253 http://dx.doi.org/10.1002/eji.201344428 |
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| Institution: | Nanyang Technological University |
| Language: | English |