Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

10.1186/s13045-017-0540-x

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Bibliographic Details
Main Authors:	Kanojia, D, Garg, M, Martinez, J, Anand, M.T, Luty, S.B, Doan, N.B, Said, J.W, Forscher, C, Tyner, J.W, Koeffler, H.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	4 amino 5 (3 benzyloxyphenyl) 7 [3 (1 pyrrolidinylmethyl)cyclobutyl] 7h pyrrolo[2,3 d]pyrimidine bortezomib CD135 antigen dasatinib elesclomol ephrin receptor A6 epidermal growth factor receptor focal adhesion kinase 1 Janus kinase 1 Janus kinase 2 macrophage stimulating 1 receptor megakaryocyte associated tyrosine kinase phosphotransferase platelet derived growth factor alpha receptor ponatinib protein kinase Fer protein kinase Syk protein tyrosine kinase protein tyrosine kinase inhibitor receptor tyrosine kinase like orphan receptor 1 RNA ROS protooncogene 1 receptor tyrosine kinase serine threonine tyrosine kinase 1 staurosporine tanespimycin tumor protein unclassified drug v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog protein vasculotropin receptor 2 imidazole derivative protein kinase inhibitor pyridazine derivative animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer growth cell cycle arrest cell cycle G0 phase cell cycle G1 phase cell cycle S phase clonogenesis concentration response controlled study drug potency drug screening enzyme analysis human human cell IC50 in vitro study in vivo study liposarcoma mouse nonhuman protein targeting RNA interference signal transduction animal cell proliferation nonobese diabetic mouse preclinical study SCID mouse Animals Cell Proliferation Drug Evaluation, Preclinical Humans Imidazoles Liposarcoma Mice Mice, Inbred NOD Mice, SCID Protein Kinase Inhibitors Pyridazines RNA Interference
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173760
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Institution:	National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/173760