Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

10.1186/s13045-017-0540-x

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Main Authors:	Kanojia, D, Garg, M, Martinez, J, Anand, M.T, Luty, S.B, Doan, N.B, Said, J.W, Forscher, C, Tyner, J.W, Koeffler, H.P
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2020
Subjects:	4 amino 5 (3 benzyloxyphenyl) 7 [3 (1 pyrrolidinylmethyl)cyclobutyl] 7h pyrrolo[2,3 d]pyrimidine bortezomib CD135 antigen dasatinib elesclomol ephrin receptor A6 epidermal growth factor receptor focal adhesion kinase 1 Janus kinase 1 Janus kinase 2 macrophage stimulating 1 receptor megakaryocyte associated tyrosine kinase phosphotransferase platelet derived growth factor alpha receptor ponatinib protein kinase Fer protein kinase Syk protein tyrosine kinase protein tyrosine kinase inhibitor receptor tyrosine kinase like orphan receptor 1 RNA ROS protooncogene 1 receptor tyrosine kinase serine threonine tyrosine kinase 1 staurosporine tanespimycin tumor protein unclassified drug v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog protein vasculotropin receptor 2 imidazole derivative protein kinase inhibitor pyridazine derivative animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer growth cell cycle arrest cell cycle G0 phase cell cycle G1 phase cell cycle S phase clonogenesis concentration response controlled study drug potency drug screening enzyme analysis human human cell IC50 in vitro study in vivo study liposarcoma mouse nonhuman protein targeting RNA interference signal transduction animal cell proliferation nonobese diabetic mouse preclinical study SCID mouse Animals Cell Proliferation Drug Evaluation, Preclinical Humans Imidazoles Liposarcoma Mice Mice, Inbred NOD Mice, SCID Protein Kinase Inhibitors Pyridazines RNA Interference
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173760
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1737602024-04-18T03:09:17Z Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets Kanojia, D Garg, M Martinez, J Anand, M.T Luty, S.B Doan, N.B Said, J.W Forscher, C Tyner, J.W Koeffler, H.P CANCER SCIENCE INSTITUTE OF SINGAPORE MEDICINE 4 amino 5 (3 benzyloxyphenyl) 7 [3 (1 pyrrolidinylmethyl)cyclobutyl] 7h pyrrolo[2,3 d]pyrimidine bortezomib CD135 antigen dasatinib elesclomol ephrin receptor A6 epidermal growth factor receptor focal adhesion kinase 1 Janus kinase 1 Janus kinase 2 macrophage stimulating 1 receptor megakaryocyte associated tyrosine kinase phosphotransferase platelet derived growth factor alpha receptor ponatinib protein kinase Fer protein kinase Syk protein tyrosine kinase protein tyrosine kinase inhibitor receptor tyrosine kinase like orphan receptor 1 RNA ROS protooncogene 1 receptor tyrosine kinase serine threonine tyrosine kinase 1 staurosporine tanespimycin tumor protein unclassified drug v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog protein vasculotropin receptor 2 imidazole derivative ponatinib protein kinase inhibitor pyridazine derivative animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer growth cell cycle arrest cell cycle G0 phase cell cycle G1 phase cell cycle S phase clonogenesis concentration response controlled study drug potency drug screening enzyme analysis human human cell IC50 in vitro study in vivo study liposarcoma mouse nonhuman protein targeting RNA interference signal transduction animal cell proliferation liposarcoma nonobese diabetic mouse preclinical study RNA interference SCID mouse Animals Cell Proliferation Drug Evaluation, Preclinical Humans Imidazoles Liposarcoma Mice Mice, Inbred NOD Mice, SCID Protein Kinase Inhibitors Pyridazines RNA Interference 10.1186/s13045-017-0540-x Journal of Hematology and Oncology 10 1 173 2020-09-01T00:48:46Z 2020-09-01T00:48:46Z 2017 Article Kanojia, D, Garg, M, Martinez, J, Anand, M.T, Luty, S.B, Doan, N.B, Said, J.W, Forscher, C, Tyner, J.W, Koeffler, H.P (2017). Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets. Journal of Hematology and Oncology 10 (1) : 173. ScholarBank@NUS Repository. https://doi.org/10.1186/s13045-017-0540-x 17568722 https://scholarbank.nus.edu.sg/handle/10635/173760 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	4 amino 5 (3 benzyloxyphenyl) 7 [3 (1 pyrrolidinylmethyl)cyclobutyl] 7h pyrrolo[2,3 d]pyrimidine bortezomib CD135 antigen dasatinib elesclomol ephrin receptor A6 epidermal growth factor receptor focal adhesion kinase 1 Janus kinase 1 Janus kinase 2 macrophage stimulating 1 receptor megakaryocyte associated tyrosine kinase phosphotransferase platelet derived growth factor alpha receptor ponatinib protein kinase Fer protein kinase Syk protein tyrosine kinase protein tyrosine kinase inhibitor receptor tyrosine kinase like orphan receptor 1 RNA ROS protooncogene 1 receptor tyrosine kinase serine threonine tyrosine kinase 1 staurosporine tanespimycin tumor protein unclassified drug v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog protein vasculotropin receptor 2 imidazole derivative ponatinib protein kinase inhibitor pyridazine derivative animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer growth cell cycle arrest cell cycle G0 phase cell cycle G1 phase cell cycle S phase clonogenesis concentration response controlled study drug potency drug screening enzyme analysis human human cell IC50 in vitro study in vivo study liposarcoma mouse nonhuman protein targeting RNA interference signal transduction animal cell proliferation liposarcoma nonobese diabetic mouse preclinical study RNA interference SCID mouse Animals Cell Proliferation Drug Evaluation, Preclinical Humans Imidazoles Liposarcoma Mice Mice, Inbred NOD Mice, SCID Protein Kinase Inhibitors Pyridazines RNA Interference
spellingShingle	4 amino 5 (3 benzyloxyphenyl) 7 [3 (1 pyrrolidinylmethyl)cyclobutyl] 7h pyrrolo[2,3 d]pyrimidine bortezomib CD135 antigen dasatinib elesclomol ephrin receptor A6 epidermal growth factor receptor focal adhesion kinase 1 Janus kinase 1 Janus kinase 2 macrophage stimulating 1 receptor megakaryocyte associated tyrosine kinase phosphotransferase platelet derived growth factor alpha receptor ponatinib protein kinase Fer protein kinase Syk protein tyrosine kinase protein tyrosine kinase inhibitor receptor tyrosine kinase like orphan receptor 1 RNA ROS protooncogene 1 receptor tyrosine kinase serine threonine tyrosine kinase 1 staurosporine tanespimycin tumor protein unclassified drug v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog protein vasculotropin receptor 2 imidazole derivative ponatinib protein kinase inhibitor pyridazine derivative animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer growth cell cycle arrest cell cycle G0 phase cell cycle G1 phase cell cycle S phase clonogenesis concentration response controlled study drug potency drug screening enzyme analysis human human cell IC50 in vitro study in vivo study liposarcoma mouse nonhuman protein targeting RNA interference signal transduction animal cell proliferation liposarcoma nonobese diabetic mouse preclinical study RNA interference SCID mouse Animals Cell Proliferation Drug Evaluation, Preclinical Humans Imidazoles Liposarcoma Mice Mice, Inbred NOD Mice, SCID Protein Kinase Inhibitors Pyridazines RNA Interference Kanojia, D Garg, M Martinez, J Anand, M.T Luty, S.B Doan, N.B Said, J.W Forscher, C Tyner, J.W Koeffler, H.P Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets
description	10.1186/s13045-017-0540-x
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Kanojia, D Garg, M Martinez, J Anand, M.T Luty, S.B Doan, N.B Said, J.W Forscher, C Tyner, J.W Koeffler, H.P
format	Article
author	Kanojia, D Garg, M Martinez, J Anand, M.T Luty, S.B Doan, N.B Said, J.W Forscher, C Tyner, J.W Koeffler, H.P
author_sort	Kanojia, D
title	Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets
title_short	Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets
title_full	Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets
title_fullStr	Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets
title_full_unstemmed	Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets
title_sort	kinase profiling of liposarcomas using rnai and drug screening assays identified druggable targets
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173760
_version_	1800914189010599936

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

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