Bioinspired pH and magnetic responsive catechol-functionalized chitosan hydrogels with tunable elastic properties

• Main Authors: Ghadban, Ali, Ahmed, Anansa S., Ping, Yuan, Ramos, Ricardo, Arfin, Najmul, Cantaert, Bram, Ramanujan, Raju Vijayaraghavan, Miserez, Ali
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2016
• Subjects: Drug release
• Online Access: https://hdl.handle.net/10356/82705; http://hdl.handle.net/10220/40289
• Institution: Nanyang Technological University

We have developed pH- and magnetic-responsive hydrogels that are stabilized by both covalent bonding and catechol/Fe3+ ligands. The viscoelastic properties of the gels are regulated by the complexation valence and can be used to tune drug release profiles. The stable incorporation of magnetic nanoparticles further expands control over the mechanical response and drug release, in addition to providing magnetic stimuli-responsivity to the gels.