Endoplasmic reticulum–plasma membrane contact sites
The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). A number of protein tethers that mediate these contacts have been identified, and study of these protein...
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sg-ntu-dr.10356-827362020-03-07T12:57:22Z Endoplasmic reticulum–plasma membrane contact sites Saheki, Yasunori De Camilli, Pietro Lee Kong Chian School of Medicine (LKCMedicine) Oxysterol-binding Protein (OSBP)–related Protein DRNTU::Science::Medicine Extended Synaptotagmins The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). A number of protein tethers that mediate these contacts have been identified, and study of these protein tethers has revealed a multiplicity of roles in cell physiology, including regulation of intracellular Ca2+ dynamics and signaling as well as control of lipid traffic and homeostasis. In this review, we discuss the cross talk between the ER and the PM mediated by direct contacts. We review factors that tether the two membranes, their properties, and their dynamics in response to the functional state of the cell. We focus in particular on the role of ER–PM contacts in nonvesicular lipid transport between the two bilayers mediated by lipid transfer proteins. 2019-07-02T06:54:38Z 2019-12-06T15:04:29Z 2019-07-02T06:54:38Z 2019-12-06T15:04:29Z 2017 Journal Article Saheki, Y., & De Camilli, P. (2017). Endoplasmic Reticulum–Plasma Membrane Contact Sites. Annual Review of Biochemistry, 86(1), 659-684. doi:10.1146/annurev-biochem-061516-044932 0066-4154 https://hdl.handle.net/10356/82736 http://hdl.handle.net/10220/49080 10.1146/annurev-biochem-061516-044932 en Annual Review of Biochemistry © 2017 Annual Reviews. All rights reserved. |
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Oxysterol-binding Protein (OSBP)–related Protein DRNTU::Science::Medicine Extended Synaptotagmins |
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Oxysterol-binding Protein (OSBP)–related Protein DRNTU::Science::Medicine Extended Synaptotagmins Saheki, Yasunori De Camilli, Pietro Endoplasmic reticulum–plasma membrane contact sites |
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The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). A number of protein tethers that mediate these contacts have been identified, and study of these protein tethers has revealed a multiplicity of roles in cell physiology, including regulation of intracellular Ca2+ dynamics and signaling as well as control of lipid traffic and homeostasis. In this review, we discuss the cross talk between the ER and the PM mediated by direct contacts. We review factors that tether the two membranes, their properties, and their dynamics in response to the functional state of the cell. We focus in particular on the role of ER–PM contacts in nonvesicular lipid transport between the two bilayers mediated by lipid transfer proteins. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Saheki, Yasunori De Camilli, Pietro |
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Article |
author |
Saheki, Yasunori De Camilli, Pietro |
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Saheki, Yasunori |
title |
Endoplasmic reticulum–plasma membrane contact sites |
title_short |
Endoplasmic reticulum–plasma membrane contact sites |
title_full |
Endoplasmic reticulum–plasma membrane contact sites |
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Endoplasmic reticulum–plasma membrane contact sites |
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Endoplasmic reticulum–plasma membrane contact sites |
title_sort |
endoplasmic reticulum–plasma membrane contact sites |
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2019 |
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https://hdl.handle.net/10356/82736 http://hdl.handle.net/10220/49080 |
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