Ca 2+ releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport

• المؤلفون الرئيسيون: Bian, Xin, Saheki, Yasunori, De Camilli, Pietro
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: C2 Domain; Extended Synaptotagmin
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87037; http://hdl.handle.net/10220/44284
• المؤسسة: Nanyang Technological University

The extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER) proteins that bind the plasma membrane (PM) via C2 domains and transport lipids between them via SMP domains. E-Syt1 tethers and transports lipids in a Ca2+-dependent manner, but the role of Ca2+ in this regulation is unclear. Of th...