Ca 2+ releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport

• Main Authors: Bian, Xin, Saheki, Yasunori, De Camilli, Pietro
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: C2 Domain; Extended Synaptotagmin
• Online Access: https://hdl.handle.net/10356/87037; http://hdl.handle.net/10220/44284
• Institution: Nanyang Technological University

The extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER) proteins that bind the plasma membrane (PM) via C2 domains and transport lipids between them via SMP domains. E-Syt1 tethers and transports lipids in a Ca2+-dependent manner, but the role of Ca2+ in this regulation is unclear. Of th...