Ca 2+ releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport

Ca 2+ releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport

The extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER) proteins that bind the plasma membrane (PM) via C2 domains and transport lipids between them via SMP domains. E-Syt1 tethers and transports lipids in a Ca2+-dependent manner, but the role of Ca2+ in this regulation is unclear. Of th...

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Bibliographic Details
Main Authors: Bian, Xin, Saheki, Yasunori, De Camilli, Pietro
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2018
Subjects:
C2 Domain
Extended Synaptotagmin
Online Access:https://hdl.handle.net/10356/87037
http://hdl.handle.net/10220/44284
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/87037
http://hdl.handle.net/10220/44284

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