Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model
Pharmacokinetics of Gd(DO3A-Lys), a macrocyclic gadolinium based MRI contrast agent functionalized with a lysine derivative, was studied in Wistar rats. Kinetic data was fitted using a two compartment model and revealed Gd(DO3A-Lys) to have a distribution half-life, t1/2(alpha), of 1.3 min, an elimi...
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sg-ntu-dr.10356-827582020-11-01T05:22:34Z Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model Chandrasekharan, Prashant Yang, Chang-Tong Nasrallah, Fatima Ali Tay, Hui Chien Chuang, Kai-Hsiang Robins, Edward G. Lee Kong Chian School of Medicine (LKCMedicine) contrast agent tumor diagnosis gadolinium chelate magnetic resonance imaging (MRI) pharmacokinetics orthotopic glioma model Pharmacokinetics of Gd(DO3A-Lys), a macrocyclic gadolinium based MRI contrast agent functionalized with a lysine derivative, was studied in Wistar rats. Kinetic data was fitted using a two compartment model and revealed Gd(DO3A-Lys) to have a distribution half-life, t1/2(alpha), of 1.3 min, an elimination half-life, t1/2(beta), of 24.9 min and a large volume of distribution, VD, of 0.49 L/kg indicative of the agent being able to rapidly distribute into tissues and organs. Contrast enhanced magnetic resonance angiography (CEMRA) in an orthotopic U87MG glioma mouse model demonstrated considerable enhancement of both the tumor and surrounding vasculature after intravenous administration of Gd(DO3A-Lys). Applying dynamic contrast enhanced magnetic resonance imaging (DCEMRI) in the glioma of different sizes further showed distinct uptake characteristics and patterns of enhancement, which suggests the potential for differentiating changes at different stages of tumor growth. Our results indicate that Gd(DO3A-Lys) could be a promising candidate for glioma MR imaging. ASTAR (Agency for Sci., Tech. and Research, S’pore) Accepted version 2016-03-23T07:23:40Z 2019-12-06T15:04:58Z 2016-03-23T07:23:40Z 2019-12-06T15:04:58Z 2015 Journal Article Chandrasekharan, P., Yang, C.-T., Nasrallah, F. A., Tay, H. C., Chuang, K.-H., & Robins, E. G. (2015). Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model. Contrast Media & Molecular Imaging, 10(3), 237-244. 1555-4309 https://hdl.handle.net/10356/82758 http://hdl.handle.net/10220/40315 10.1002/cmmi.1634 en Contrast Media & Molecular Imaging © 2015 John Wiley & Sons, Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Contrast Media and Molecular Imaging, John Wiley & Sons, Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/cmmi.1634]. 26 p. application/pdf |
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contrast agent tumor diagnosis gadolinium chelate magnetic resonance imaging (MRI) pharmacokinetics orthotopic glioma model Chandrasekharan, Prashant Yang, Chang-Tong Nasrallah, Fatima Ali Tay, Hui Chien Chuang, Kai-Hsiang Robins, Edward G. Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model |
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Pharmacokinetics of Gd(DO3A-Lys), a macrocyclic gadolinium based MRI contrast agent functionalized with a lysine derivative, was studied in Wistar rats. Kinetic data was fitted using a two compartment model and revealed Gd(DO3A-Lys) to have a distribution half-life, t1/2(alpha), of 1.3 min, an elimination half-life, t1/2(beta), of 24.9 min and a large volume of distribution, VD, of 0.49 L/kg indicative of the agent being able to rapidly distribute into tissues and organs. Contrast enhanced magnetic resonance angiography (CEMRA) in an orthotopic U87MG glioma mouse model demonstrated considerable enhancement of both the tumor and surrounding vasculature after intravenous administration of Gd(DO3A-Lys). Applying dynamic contrast enhanced magnetic resonance imaging (DCEMRI) in the glioma of different sizes further showed distinct uptake characteristics and patterns of enhancement, which suggests the potential for differentiating changes at different stages of tumor growth. Our results indicate that Gd(DO3A-Lys) could be a promising candidate for glioma MR imaging. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Chandrasekharan, Prashant Yang, Chang-Tong Nasrallah, Fatima Ali Tay, Hui Chien Chuang, Kai-Hsiang Robins, Edward G. |
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Article |
author |
Chandrasekharan, Prashant Yang, Chang-Tong Nasrallah, Fatima Ali Tay, Hui Chien Chuang, Kai-Hsiang Robins, Edward G. |
author_sort |
Chandrasekharan, Prashant |
title |
Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model |
title_short |
Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model |
title_full |
Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model |
title_fullStr |
Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model |
title_full_unstemmed |
Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model |
title_sort |
pharmacokinetics of gd(do3a-lys) and mr imaging studies in an orthotopic u87mg glioma tumor model |
publishDate |
2016 |
url |
https://hdl.handle.net/10356/82758 http://hdl.handle.net/10220/40315 |
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1683493904620453888 |