Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model

• Main Authors: Chandrasekharan, Prashant, Yang, Chang-Tong, Nasrallah, Fatima Ali, Tay, Hui Chien, Chuang, Kai-Hsiang, Robins, Edward G.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: contrast agent; tumor diagnosis; gadolinium chelate; magnetic resonance imaging (MRI); pharmacokinetics; orthotopic glioma model
• Online Access: https://hdl.handle.net/10356/82758; http://hdl.handle.net/10220/40315
• Institution: Nanyang Technological University

Pharmacokinetics of Gd(DO3A-Lys), a macrocyclic gadolinium based MRI contrast agent functionalized with a lysine derivative, was studied in Wistar rats. Kinetic data was fitted using a two compartment model and revealed Gd(DO3A-Lys) to have a distribution half-life, t1/2(alpha), of 1.3 min, an elimi...