Pharmacokinetics of Gd(DO3A-Lys) and MR imaging studies in an orthotopic U87MG glioma tumor model

• Main Authors: Chandrasekharan, Prashant, Yang, Chang-Tong, Nasrallah, Fatima Ali, Tay, Hui Chien, Chuang, Kai-Hsiang, Robins, Edward G.
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2016
• 主題: contrast agent; tumor diagnosis; gadolinium chelate; magnetic resonance imaging (MRI); pharmacokinetics; orthotopic glioma model
• 在線閱讀: https://hdl.handle.net/10356/82758; http://hdl.handle.net/10220/40315

Pharmacokinetics of Gd(DO3A-Lys), a macrocyclic gadolinium based MRI contrast agent functionalized with a lysine derivative, was studied in Wistar rats. Kinetic data was fitted using a two compartment model and revealed Gd(DO3A-Lys) to have a distribution half-life, t1/2(alpha), of 1.3 min, an elimi...