A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose

A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose

A triosmium carbonyl cluster–boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent...

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Bibliographic Details
Main Authors: Kong, Kien Voon, Lam, Zhiyong, Lau, Weber Kam On, Leong, Weng Kee, Olivo, Malini
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2016
Subjects:
Carbonylation
Glucose
Online Access:https://hdl.handle.net/10356/82760
http://hdl.handle.net/10220/40318
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Institution: Nanyang Technological University
Language: English
Description
Summary:A triosmium carbonyl cluster–boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800–2200 cm–1), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately.

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