A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose
A triosmium carbonyl cluster–boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent...
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sg-ntu-dr.10356-827602023-02-28T19:30:25Z A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose Kong, Kien Voon Lam, Zhiyong Lau, Weber Kam On Leong, Weng Kee Olivo, Malini School of Physical and Mathematical Sciences Carbonylation Glucose A triosmium carbonyl cluster–boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800–2200 cm–1), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately. ASTAR (Agency for Sci., Tech. and Research, S’pore) Accepted version 2016-03-23T07:55:18Z 2019-12-06T15:05:01Z 2016-03-23T07:55:18Z 2019-12-06T15:05:01Z 2013 Journal Article Kong, K. V., Lam, Z., Lau, W. K. O., Leong, W. K., & Olivo, M. (2013). A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose. Journal of the American Chemical Society, 135(48), 18028-18031. 0002-7863 https://hdl.handle.net/10356/82760 http://hdl.handle.net/10220/40318 10.1021/ja409230g en Journal of the American Chemical Society © 2013 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of the American Chemical Society, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/ja409230g]. 7 P. application/pdf |
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Carbonylation Glucose |
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Carbonylation Glucose Kong, Kien Voon Lam, Zhiyong Lau, Weber Kam On Leong, Weng Kee Olivo, Malini A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose |
| description |
A triosmium carbonyl cluster–boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800–2200 cm–1), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Kong, Kien Voon Lam, Zhiyong Lau, Weber Kam On Leong, Weng Kee Olivo, Malini |
| format |
Article |
| author |
Kong, Kien Voon Lam, Zhiyong Lau, Weber Kam On Leong, Weng Kee Olivo, Malini |
| author_sort |
Kong, Kien Voon |
| title |
A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose |
| title_short |
A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose |
| title_full |
A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose |
| title_fullStr |
A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose |
| title_full_unstemmed |
A Transition Metal Carbonyl Probe for Use in a Highly Specific and Sensitive SERS-Based Assay for Glucose |
| title_sort |
transition metal carbonyl probe for use in a highly specific and sensitive sers-based assay for glucose |
| publishDate |
2016 |
| url |
https://hdl.handle.net/10356/82760 http://hdl.handle.net/10220/40318 |
| _version_ |
1759855813865766912 |