Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

• Main Authors: Posthuma, Danielle, Andreassen, Ole A., Karch, Celeste M., Desikan, Rahul S., Broce, Iris J., Tan, Chin Hong, Fan, Chun Chieh, Jansen, Iris, Savage, Jeanne E., Witoelar, Aree, Wen, Natalie, Hess, Christopher P., Dillon, William P., Glastonbury, Christine M., Glymour, Maria, Yokoyama, Jennifer S., Elahi, Fanny M., Rabinovici, Gil D., Miller, Bruce L., Mormino, Elizabeth C., Sperling, Reisa A., Bennett, David A., McEvoy, Linda K., Brewer, James B., Feldman, Howard H., Hyman, Bradley T., Pericak-Vance, Margaret, Haines, Jonathan L., Farrer, Lindsay A., Mayeux, Richard, Schellenberg, Gerard D., Yaffe, Kristine, Sugrue, Leo P., Dale, Anders M.
• Other Authors: School of Social Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Polygenic Enrichment; Social sciences::Psychology; Lipids
• Online Access: https://hdl.handle.net/10356/82843; http://hdl.handle.net/10220/50292
• Institution: Nanyang Technological University

Cardiovascular (CV)- and lifestyle-associated risk factors (RFs) are increasingly recognized as important for Alzheimer’s disease (AD) pathogenesis. Beyond the ε4 allele of apolipoprotein E (APOE), comparatively little is known about whether CV-associated genes also increase risk for AD. Using large...