Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

• المؤلفون الرئيسيون: Posthuma, Danielle, Andreassen, Ole A., Karch, Celeste M., Desikan, Rahul S., Broce, Iris J., Tan, Chin Hong, Fan, Chun Chieh, Jansen, Iris, Savage, Jeanne E., Witoelar, Aree, Wen, Natalie, Hess, Christopher P., Dillon, William P., Glastonbury, Christine M., Glymour, Maria, Yokoyama, Jennifer S., Elahi, Fanny M., Rabinovici, Gil D., Miller, Bruce L., Mormino, Elizabeth C., Sperling, Reisa A., Bennett, David A., McEvoy, Linda K., Brewer, James B., Feldman, Howard H., Hyman, Bradley T., Pericak-Vance, Margaret, Haines, Jonathan L., Farrer, Lindsay A., Mayeux, Richard, Schellenberg, Gerard D., Yaffe, Kristine, Sugrue, Leo P., Dale, Anders M.
• مؤلفون آخرون: School of Social Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Polygenic Enrichment; Social sciences::Psychology; Lipids
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82843; http://hdl.handle.net/10220/50292
• المؤسسة: Nanyang Technological University

Cardiovascular (CV)- and lifestyle-associated risk factors (RFs) are increasingly recognized as important for Alzheimer’s disease (AD) pathogenesis. Beyond the ε4 allele of apolipoprotein E (APOE), comparatively little is known about whether CV-associated genes also increase risk for AD. Using large...