Molecular basis for specific viral RNA recognition and 2' -O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

• المؤلفون الرئيسيون: Zhao, Yongqian, Soh, Tingjin Sherryl, Lim, Siew Pheng, Chung, Ka Yan, Swaminathan, Kunchithapadam, Vasudevan, Subhash G., Shi, Pei-Yong, Lescar, Julien, Luo, Dahai
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: 2′-O-ribose methyltransferase; Dengue virus; Nonstructural protein 5 methyltransferase-polymerase; Cap-0 RNA; Innate immunity evasion
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82917; http://hdl.handle.net/10220/40374
• المؤسسة: Nanyang Technological University

Dengue virus (DENV) causes several hundred million human infections and more than 20,000 deaths annually. Neither an efficacious vaccine conferring immunity against all four circulating serotypes nor specific drugs are currently available to treat this emerging global disease. Capping of the DENV RN...