Targeting the Achilles heel of mosquito-borne viruses for antiviral therapy

by Jackman, Joshua A., Shi, Pei-Yong, Cho, Nam-Joon
Published 2021

Conformational flexibility of the dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor

by Yap, Lijian, Lescar, Julien, Noble, Christian G., Lim, Siew Pheng, Chen, Yen-Liang, Liew, Chong Wai, Shi, Pei-Yong
Published 2015

Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

by Li, Yan, Wong, Ying Lei, Lee, Michelle Yueqi, Li, Qingxin, Wang, Qing-Yin, Lescar, Julien, Shi, Pei-Yong, Kang, CongBao
Published 2017

NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its Zika virus and Japanese encephalitis virus homologues

by El Sahili, Abbas, Soh, Sherryl Tingjin, Schiltz, Jonas, Gharbi-Ayachi, Aïcha, Seh, Cheah Chen, Shi, Pei-Yong, Lim, Siew Pheng, Lescar, Julien
Published 2020

Molecular basis for specific viral RNA recognition and 2' -O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

by Zhao, Yongqian, Soh, Tingjin Sherryl, Lim, Siew Pheng, Chung, Ka Yan, Swaminathan, Kunchithapadam, Vasudevan, Subhash G., Shi, Pei-Yong, Lescar, Julien, Luo, Dahai
Published 2016

Mapping the interactions between the NS4B and NS3 proteins of dengue virus

by Zou, Jing, Lee, Le Tian, Wang, Qing Yin, Xie, Xuping, Lu, Siyan, Yau, Yin Hoe, Yuan, Zhiming, Geifman Shochat, Susana, Kang, Congbao, Lescar, Julien, Shi, Pei-Yong
Published 2015

Dimerization of flavivirus NS4B protein

by Dong, Hongping, Reynaud, Aline, Zou, Jing, Xie, Xuping, Lee, Le Tian, Chandrasekaran, Ramya, Yap, Lijian, Wang, Qing-Yin, Kang, Congbao, Yuan, Zhiming, Lescar, Julien, Shi, Pei-Yong
Published 2015

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

by Zhao, Yongqian, Soh, Tingjin Sherryl, Chan, Kitti Wing Ki, Fung, Sarah Suet Yin, Swaminathan, Kunchithapadam, Lim, Siew Pheng, Shi, Pei-Yong, Huber, Thomas, Lescar, Julien, Luo, Dahai, Vasudevan, Subhash G.
Published 2015

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C

by Lim, Xin-Ni, Shan, Chao, Marzinek, Jan K., Dong, Hongping, Ng, Thiam Seng, Ooi, Justin Seng Geap, Fibriansah, Guntur, Wang, Jiaqi, Verma, Chandra Shekhar, Bond, Peter John, Shi, Pei-Yong, Lok, Shee-mei
Published 2020

A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

by Zhao, Yongqian, Soh, Tingjin Sherryl, Zheng, Jie, Chan, Kitti Wing Ki, Phoo, Wint Wint, Lee, Chin Chin, Tay, Moon Y. F., Swaminathan, Kunchithapadam, Cornvik, Tobias Carl, Lim, Siew Pheng, Shi, Pei-Yong, Lescar, Julien, Vasudevan, Subhash G., Luo, Dahai
Published 2015

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

by Wang, Jin, Chew, Alvin Bing Liang, Lai, Yong, Dong, Hongping, Xu, Luang, Balamkundu, Seetharamsingh, Cai, Maggie Weiling, Cui, Liang, Liu, Chuan Fa, Fu, Xin-Yuan, Lin, Zhenguo, Shi, Pei-Yong, Lu, Timothy K., Luo, Dahai, Jaffrey, Samie R., Dedon, Peter C.
Published 2020

Two RNA tunnel inhibitors bind in highly conserved sites in dengue virus NS5 polymerase : structural and functional studies

by Arora, Rishi, Liew, Chong Wai, Soh, Sherryl Tingjin, Otoo, Dorcas Adobea, Seh, Cheah Chen, Yue, Kimberley, Shahul Nilar, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian G., Chen, Yen Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas M., Benson, Timothy E., Lim, Siew Pheng
Published 2021

A multidimensional platform for the purification of non-coding RNA species

by Ho, Chia-Hua, Pruksakorn, Dumnoensun, Babu, I. Ramesh, Ng, Chee Sheng, Hia, Fabian, Chionh, Yok Hian, McBee, Megan E., Su, Dan, Pang, Yan Ling Joy, Gu, Chen, Dong, Hongping, Prestwich, Erin G., Shi, Pei-Yong, Preiser, Peter Rainer, Alonso, Sylvie, Dedon, Peter C.
Published 2013

Dengue and Zika RNA-RNA interactomes reveal pro- and anti-viral RNA in human cells

by Liao, Kuo-Chieh, Xie, Xuping, Sundstrom, Anna Karin Beatrice, Lim, Xin Ni, Tan, Kiat Kee, Zhang, Yu, Zou, Jing, Bifani, Amanda Makha, Poh, Hui Xian, Chen, Jia Jia, Ng, Wy Ching, Lim, Su Ying, Ooi, Eng Eong, Sessions, October M., Tay, Yvonne, Shi, Pei-Yong, Huber, Roland G., Wan, Yue
Published 2024

Discovery of Dengue Virus NS4B Inhibitors

by Wang, Qing-Yin, Dong, Hongping, Zou, Bin, Karuna, Ratna, Wan, Kah Fei, Zou, Jing, Susila, Agatha, Yip, Andy, Shan, Chao, Yeo, Kim Long, Xu, Haoying, Ding, Mei, Chan, Wai Ling, Gu, Feng, Seah, Peck Gee, Liu, Wei, Lakshminarayana, Suresh B., Kang, CongBao, Lescar, Julien, Blasco, Francesca, Smith, Paul W., Shi, Pei-Yong
Published 2015

Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

by Ku, Zhiqiang, Xie, Xuping, Lin, Jianqing, Gao, Peng, Wu, Bin, El Sahili, Abbas, Su, Hang, Liu, Yang, Ye, Xiaohua, Tan, Eddie Yongjun, Li, Xin, Fan, Xuejun, Goh, Boon Chong, Xiong, Wei, Boyd, Hannah, Muruato, Antonio E., Deng, Hui, Xia, Hongjie, Zou, Jing, Kalveram, Birte K., Menachery, Vineet D., Zhang, Ningyan, Lescar, Julien, Shi, Pei-Yong, An, Zhiqiang
Published 2023

Structural and interaction studies of the NS4B integral membrane protein from dengue virus

by Lee, Le Tian
Published 2017