Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles

• المؤلفون الرئيسيون: Li, Yan, Wong, Ying Lei, Lee, Michelle Yueqi, Li, Qingxin, Wang, Qing-Yin, Lescar, Julien, Shi, Pei-Yong, Kang, CongBao
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Dengue-Virus; Membranproteine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/83047; http://hdl.handle.net/10220/42374

Dengue virus nonstructural protein 4B (NS4B) is a membrane protein consisting of 248 residues with a crucial role in virus replication and interference with the host innate immunity. The dengue virus serotype 3 NS4B was reconstituted into lyso-myristoyl phosphatidylglycerol (LMPG) micelles. Backbone...