Dynamic DNA methylation landscape defines brown and white cell specificity during adipogenesis

• Main Authors: Lim, Yen Ching, Chia, Sook Yoong, Jin, Shengnan, Han, Weiping, Ding, Chunming, Sun, Lei
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Brown adipogenesis; White adipogenesis
• Online Access: https://hdl.handle.net/10356/83034; http://hdl.handle.net/10220/42372
• Institution: Nanyang Technological University

Objective: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. Methods: We performed reduced representation bisulfite sequencing (RRBS) and RNA-seq to depict a genome-wide integrative view of the DNA methylome and transcriptome during brown and white adipogenesis....