Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms

• Main Authors: Yap, Karen, Xiao, Yixin, Friedman, Brad A., Je, H. Shawn, Makeyev, Eugene V.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Eukaryotic proteomes; Cdc42 in neurons
• Online Access: https://hdl.handle.net/10356/83051; http://hdl.handle.net/10220/42371
• Institution: Nanyang Technological University

Alternative splicing (AS) is an important source of proteome diversity in eukaryotes. However, how this affects protein repertoires at a single-cell level remains an open question. Here, we show that many 30-terminal exons are persistently co-expressed with their alternatives in mammalian neuro...