A semiconducting polymer nano-prodrug for hypoxia-activated synergetic photodynamic cancer therapy

• Main Authors: Cui, Dong, Huang, Jiaguo, Zhen, Xu, Li, Jingchao, Jiang, Yuyan, Pu, Kanyi
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Photodynamic Therapy; Cancer Therapy; Engineering::Chemical engineering
• Online Access: https://hdl.handle.net/10356/83296; http://hdl.handle.net/10220/50100
• Institution: Nanyang Technological University

Photodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1O2) under NIR photoirradiation but also...