A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

• Main Authors: Murima, Paul, Zimmermann, Michael, Chopra, Tarun, Pojer, Florence, Fonti, Giulia, Dal Peraro, Matteo, Alonso, Sylvie, Sauer, Uwe, Pethe, Kevin, McKinney, John D.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Bacterial genetics; Biochemical networks
• Online Access: https://hdl.handle.net/10356/83396; http://hdl.handle.net/10220/41416
• Institution: Nanyang Technological University

Fatty acid metabolism is an important feature of the pathogenicity of Mycobacterium tuberculosis during infection. Consumption of fatty acids requires regulation of carbon flux bifurcation between the oxidative TCA cycle and the glyoxylate shunt. In Escherichia coli, flux bifurcation is regulated by...