Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies

Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies

Many transition metal complexes have unique physicochemical properties that can be efficiently exploited in medicinal chemistry for cancer treatment. Traditionally, double-stranded DNA has been assumed to be the main binding target; however, recent studies have shown that nucleosomal DNA as well as...

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Bibliographic Details
Main Authors: Palermo, Giulia, Magistrato, Alessandra, Riedel, Tina, Erlach, Thibaud von, Davey, Curt Alexander, Dyson, Paul J., Rothlisberger, Ursula
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2016
Subjects:
drug design
metal complexes
Online Access:https://hdl.handle.net/10356/83407
http://hdl.handle.net/10220/41407
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/83407
http://hdl.handle.net/10220/41407

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