Choline Ameliorates Disease Phenotypes in Human iPSC Models of Rett Syndrome

Rett syndrome (RTT) is a postnatal neurodevelopmental disorder that primarily affects girls. Mutations in the methyl-CpG-binding protein 2 (MECP2) gene account for approximately 95 % of all RTT cases. To model RTT in vitro, we generated induced pluripotent stem cells (iPSCs) from fibroblasts of two...

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Bibliographic Details
Main Authors: Chin, Eunice W. M., Marcy, Guillaume, Yoon, Su-In, Ma, Dongliang, Rosales, Francisco J., Augustine, George James, Goh, Eyleen Lay Keow
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2016
Subjects:
Online Access:https://hdl.handle.net/10356/83417
http://hdl.handle.net/10220/41418
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Institution: Nanyang Technological University
Language: English