Choline Ameliorates Disease Phenotypes in Human iPSC Models of Rett Syndrome

• Main Authors: Chin, Eunice W. M., Marcy, Guillaume, Yoon, Su-In, Ma, Dongliang, Rosales, Francisco J., Augustine, George James, Goh, Eyleen Lay Keow
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Choline; Human iPSC
• Online Access: https://hdl.handle.net/10356/83417; http://hdl.handle.net/10220/41418
• Institution: Nanyang Technological University

Rett syndrome (RTT) is a postnatal neurodevelopmental disorder that primarily affects girls. Mutations in the methyl-CpG-binding protein 2 (MECP2) gene account for approximately 95 % of all RTT cases. To model RTT in vitro, we generated induced pluripotent stem cells (iPSCs) from fibroblasts of two...