TLR7 protein expression in mild and severe lupus-prone models is regulated in a leukocyte, genetic, and IRAK4 dependent manner

• Main Authors: Celhar, Teja, Lu, Hao Kim, Benso, Lia, Rakhilina, Larissa, Lee, Hui Yin, Tripathi, Shubhita, Zharkova, Olga, Ong, Wei Yee, Yasuga, Hiroko, Au, Bijin, Marlier, Damien, Lim, Lina Hsiu Kim, Thamboo, Thomas Paulraj, Mudgett, John S., Mackey, Matthew F., Zaller, Dennis M., Connolly, John E., Fairhurst, Anna-Marie
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: IRAK4; Science::Biological sciences; TLR7
• Online Access: https://hdl.handle.net/10356/83531; http://hdl.handle.net/10220/49759
• Institution: Nanyang Technological University

The global increase in autoimmunity, together with the emerging autoimmune-related side effects of cancer immunotherapy, have furthered a need for understanding of immune tolerance and activation. Systemic lupus erythematosus (SLE) is the archetypical autoimmune disease, affecting multiple organs, a...