EthA/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide

• المؤلفون الرئيسيون: Ang, Michelle L. T., Zainul Rahim, Siti Z., de Sessions, Paola Florez, Lin, Wenwei, Koh, Vanessa, Pethe, Kevin, Hibberd, Martin L., Alonso, Sylvie
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Ethionamide; Mycobacterium tuberculosis
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/83568; http://hdl.handle.net/10220/42676

Ethionamide (ETH) is part of the drug arsenal available to treat multi-drug resistant tuberculosis. The current paradigm of this pro-drug activation involves the mycobacterial enzyme EthA and the transcriptional repressor, EthR. However, several lines of evidence suggest the involvement of additiona...