Nerve regeneration by human corneal stromal keratocytes and stromal fibroblasts

• Main Authors: Yam, Gary Hin-Fai, Williams, Geraint P., Setiawan, Melina, Yusoff, Nur Zahirah Binte M., Lee, Xiao-wen, Htoon, Hla Myint, Zhou, Lei, Fuest, Matthias, Mehta, Jodhbir Singh
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Cell growth; Translational research
• Online Access: https://hdl.handle.net/10356/83580; http://hdl.handle.net/10220/42667
• Institution: Nanyang Technological University

Laser refractive surgeries reshape corneal stroma to correct refractive errors, but unavoidably affect corneal nerves. Slow nerve regeneration and atypical neurite morphology cause desensitization and neuro-epitheliopathy. Following injury, surviving corneal stromal keratocytes (CSKs) are activated...