Mechanisms of Yersinia YopO kinase substrate specificity

• Main Authors: Lee, Wei Lin, Singaravelu, Pavithra, Wee, Sheena, Xue, Bo, Ang, Khay Chun, Gunaratne, Jayantha, Grimes, Jonathan M., Swaminathan, Kunchithapadam, Robinson, Robert C.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Protein–protein interaction networks; Phosphorylation
• Online Access: https://hdl.handle.net/10356/83602; http://hdl.handle.net/10220/42660
• Institution: Nanyang Technological University

Yersinia bacteria cause a range of human diseases, including yersiniosis, Far East scarlet-like fever and the plague. Yersiniae modulate and evade host immune defences through injection of Yersinia outer proteins (Yops) into phagocytic cells. One of the Yops, YopO (also known as YpkA) obstructs phag...