Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation

• المؤلفون الرئيسيون: Berglund, Ken, Clissold, Kara, Li, Haofang E., Wen, Lei, Park, Sung Young, Gleixner, Jan, Klein, Marguerita E., Lu, Dongye, Barter, Joseph W., Rossi, Mark A., Augustine, George James, Yin, Henry H., Hochgeschwender, Ute
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Bioluminescence; Neural circuitry; Substantia nigra; Hippocampus; Luciferase
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/83769; http://hdl.handle.net/10220/39946

Luminopsins are fusion proteins of luciferase and opsin that allow interrogation of neuronal circuits at different temporal and spatial resolutions by choosing either extrinsic physical or intrinsic biological light for its activation. Building on previous development of fusions of wild-type Gaussia...