Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation

• Main Authors: Berglund, Ken, Clissold, Kara, Li, Haofang E., Wen, Lei, Park, Sung Young, Gleixner, Jan, Klein, Marguerita E., Lu, Dongye, Barter, Joseph W., Rossi, Mark A., Augustine, George James, Yin, Henry H., Hochgeschwender, Ute
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Bioluminescence; Neural circuitry; Substantia nigra; Hippocampus; Luciferase
• Online Access: https://hdl.handle.net/10356/83769; http://hdl.handle.net/10220/39946
• Institution: Nanyang Technological University

Luminopsins are fusion proteins of luciferase and opsin that allow interrogation of neuronal circuits at different temporal and spatial resolutions by choosing either extrinsic physical or intrinsic biological light for its activation. Building on previous development of fusions of wild-type Gaussia...