mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues
MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA destabilization, with mRNA destabilization dominating at steady state in the few contexts examined globally. Here, we extend the global steady-state measurements to additional mammalian contexts and f...
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Main Authors: | Eichhorn, Stephen W., Guo, Huili, McGeary, Sean E., Rodriguez-Mias, Ricard A., Shin, Chanseok, Baek, Daehyun, Hsu, Shu-hao, Ghoshal, Kalpana, Villén, Judit, Bartel, David P. |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2016
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/83818 http://hdl.handle.net/10220/41504 |
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Institution: | Nanyang Technological University |
Language: | English |
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