Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter

• Main Authors: Salvi, Amrita, Thanabalu, Thirumaran
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: N-WASP; Hypoxia
• Online Access: https://hdl.handle.net/10356/83924; http://hdl.handle.net/10220/42886
• Institution: Nanyang Technological University

Cancer cell migration and invasion involves temporal and spatial regulation of actin cytoskeleton reorganization, which is regulated by the WASP family of proteins such as N-WASP (Neural- Wiskott Aldrich Syndrome Protein). We have previously shown that expression of N-WASP was increased under hypoxi...