Modulating release of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization

• Main Authors: Moreno, Miguel, Pow, Poh Yih, Tan, Su Teng Tabitha, Nirmal, Sonali, Larsson, Andreas, Radhakrishnan, Krishna, Nirmal, Jayabalan, Quah, Soo Tng, Shochat, Susana Geifman, Agrawal, Rupesh, Venkatraman, Subbu S.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Thiolated chitosan-based hydrogels; Anti-vascular endothelial growth factor proteins
• Online Access: https://hdl.handle.net/10356/84063; http://hdl.handle.net/10220/42956
• Institution: Nanyang Technological University

Background: This paper describes the synthesis of thiolated chitosan-based hydrogels with varying degrees of crosslinking that has been utilized to modulate release kinetics of two clinically relevant FDA-approved anti-VEGF protein drugs, ranibizumab and aflibercept. These hydrogels have been fabric...