Bladder catheterization increases susceptibility to infection that can be prevented by prophylactic antibiotic treatment

• Main Authors: Rousseau, Matthieu, Goh, Hwee Mian Sharon, Holec, Sarah, Albert, Matthew L., Williams, Rohan B.H., Ingersoll, Molly A., Kline, Kimberly A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Catheterization; Infections
• Online Access: https://hdl.handle.net/10356/84078; http://hdl.handle.net/10220/42943
• Institution: Nanyang Technological University

Catheter-associated urinary tract infections (CAUTI) are the most common hospital-associated infections. Here, we report that bladder catheterization initiated a persistent sterile inflammatory reaction within minutes of catheter implantation. Catheterization resulted in increased expression of gene...