In vitro and in vivo generation and characterization of Pseudomonas aeruginosa biofilm–dispersed cells via c-di-GMP manipulation

• Main Authors: Chua, Song Lin, Hultqvist, Louise D., Yuan, Mingjun, Rybtke, Morten, Nielsen, Thomas E., Givskov, Michael, Tolker-Nielsen, Tim, Yang, Liang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Biofilm dispersal; Pseudomonas aeruginosa
• Online Access: https://hdl.handle.net/10356/84100; http://hdl.handle.net/10220/43562
• Institution: Nanyang Technological University

Bis-(3′-5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a global secondary bacterial messenger that controls the formation of drug-resistant multicellular biofilms. Lowering the intracellular c-di-GMP content can disperse biofilms, and it is proposed as a biofilm eradication strategy. Howev...