Exaptive origins of regulated mRNA decay in eukaryotes

Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense-mediated decay (NMD) and motif-specific transcript de...

Full description

Saved in:
Bibliographic Details
Main Authors: Hamid, Fursham Muhammad, Makeyev, Eugene V.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2016
Subjects:
Online Access:https://hdl.handle.net/10356/84109
http://hdl.handle.net/10220/41600
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-84109
record_format dspace
spelling sg-ntu-dr.10356-841092023-02-28T17:04:47Z Exaptive origins of regulated mRNA decay in eukaryotes Hamid, Fursham Muhammad Makeyev, Eugene V. School of Biological Sciences exaptation mRNA decay Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense-mediated decay (NMD) and motif-specific transcript destabilization by CCCH-type zinc finger RNA-binding proteins, originated as a part of cellular defense against RNA pathogens. These branches of the mRNA turnover pathway might have been used by primeval eukaryotes alongside RNA interference to distinguish their own messages from those of RNA viruses and retrotransposable elements. We further hypothesize that the subsequent advent of “professional” innate and adaptive immunity systems allowed NMD and the motif-triggered mechanisms to be efficiently repurposed for regulation of endogenous cellular transcripts. This scenario explains the rapid emergence of archetypical mRNA destabilization pathways in eukaryotes and argues that other aspects of post-transcriptional gene regulation in this lineage might have been derived through a similar exaptation route. NMRC (Natl Medical Research Council, S’pore) Published version 2016-11-01T07:35:33Z 2019-12-06T15:38:33Z 2016-11-01T07:35:33Z 2019-12-06T15:38:33Z 2016 Journal Article Hamid, F. M., & Makeyev, E. V. (2016). Exaptive origins of regulated mRNA decay in eukaryotes. BioEssays, 38(9), 830-838. 0265-9247 https://hdl.handle.net/10356/84109 http://hdl.handle.net/10220/41600 10.1002/bies.201600100 27438915 en BioEssays © 2016 The Authors (published by WILEY Periodicals, Inc.) This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. 9 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic exaptation
mRNA decay
spellingShingle exaptation
mRNA decay
Hamid, Fursham Muhammad
Makeyev, Eugene V.
Exaptive origins of regulated mRNA decay in eukaryotes
description Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense-mediated decay (NMD) and motif-specific transcript destabilization by CCCH-type zinc finger RNA-binding proteins, originated as a part of cellular defense against RNA pathogens. These branches of the mRNA turnover pathway might have been used by primeval eukaryotes alongside RNA interference to distinguish their own messages from those of RNA viruses and retrotransposable elements. We further hypothesize that the subsequent advent of “professional” innate and adaptive immunity systems allowed NMD and the motif-triggered mechanisms to be efficiently repurposed for regulation of endogenous cellular transcripts. This scenario explains the rapid emergence of archetypical mRNA destabilization pathways in eukaryotes and argues that other aspects of post-transcriptional gene regulation in this lineage might have been derived through a similar exaptation route.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Hamid, Fursham Muhammad
Makeyev, Eugene V.
format Article
author Hamid, Fursham Muhammad
Makeyev, Eugene V.
author_sort Hamid, Fursham Muhammad
title Exaptive origins of regulated mRNA decay in eukaryotes
title_short Exaptive origins of regulated mRNA decay in eukaryotes
title_full Exaptive origins of regulated mRNA decay in eukaryotes
title_fullStr Exaptive origins of regulated mRNA decay in eukaryotes
title_full_unstemmed Exaptive origins of regulated mRNA decay in eukaryotes
title_sort exaptive origins of regulated mrna decay in eukaryotes
publishDate 2016
url https://hdl.handle.net/10356/84109
http://hdl.handle.net/10220/41600
_version_ 1759857762446082048