Exaptive origins of regulated mRNA decay in eukaryotes

• Main Authors: Hamid, Fursham Muhammad, Makeyev, Eugene V.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: exaptation; mRNA decay
• Online Access: https://hdl.handle.net/10356/84109; http://hdl.handle.net/10220/41600
• Institution: Nanyang Technological University

Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense-mediated decay (NMD) and motif-specific transcript de...