High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine

• Main Authors: Duszka, Kalina, Burcelin, Rémy, Wahli, Walter, Sansonetti, Philippe J., Pédron, Thierry, Tomas, Julie, Mulet, Céline, Saffarian, Azadeh, Cavin, Jean-Baptiste, Ducroc, Robert, Regnault, Béatrice, Tan, Chek Kun
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: High-fat diet; Microbiota
• Online Access: https://hdl.handle.net/10356/84359; http://hdl.handle.net/10220/41791
• Institution: Nanyang Technological University

Diet is among the most important factors contributing to intestinal homeostasis, and basic functions performed by the small intestine need to be tightly preserved to maintain health. Little is known about the direct impact of high-fat (HF) diet on small-intestinal mucosal defenses and spatial distri...