Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffol...

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Main Authors: Fang, Yiwen, Fullwood, Melissa Jane
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2016
Subjects:
lncRNAs
Chromatin
Online Access:https://hdl.handle.net/10356/84600
http://hdl.handle.net/10220/41878
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Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-84600
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spelling sg-ntu-dr.10356-846002023-02-28T17:01:07Z Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer Fang, Yiwen Fullwood, Melissa Jane School of Biological Sciences lncRNAs Chromatin Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) Published version 2016-12-16T08:46:38Z 2019-12-06T15:48:05Z 2016-12-16T08:46:38Z 2019-12-06T15:48:05Z 2016 Journal Article Fang, Y., & Fullwood, M. J. (2016). Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer. Genomics, Proteomics & Bioinformatics, 14(1), 42-54. 1672-0229 https://hdl.handle.net/10356/84600 http://hdl.handle.net/10220/41878 10.1016/j.gpb.2015.09.006 26883671 en Genomics, Proteomics & Bioinformatics © 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 13 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic lncRNAs
Chromatin
spellingShingle lncRNAs
Chromatin
Fang, Yiwen
Fullwood, Melissa Jane
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
description Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Fang, Yiwen
Fullwood, Melissa Jane
format Article
author Fang, Yiwen
Fullwood, Melissa Jane
author_sort Fang, Yiwen
title Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
title_short Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
title_full Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
title_fullStr Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
title_full_unstemmed Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
title_sort roles, functions, and mechanisms of long non-coding rnas in cancer
publishDate 2016
url https://hdl.handle.net/10356/84600
http://hdl.handle.net/10220/41878
_version_ 1759856573768794112

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